A multi-state operation with the Drug Enforcement Administration and three state law enforcement teams resulted in 375 arrests and 800 pounds of meth seized.

Dubbed 'Operation Crystal Mountain,' the months-long effort targeted Mexican drug cartels, drug trafficking organizations and other individuals involved in the manufacturing and distribution of methamphetamine according to the DEA.

Law enforcement also collected 52 firearms and large amounts of heroin, fentanyl and other illicit drugs during the operation, along with more than $800,000 in cash, according to the release.

Federal agents arrested 235 people on federal drug-related charges while an additional 140 people were arrested by state or local agencies on state-level drug charges.

Of the federal arrests that resulted from the operation, the vast majority were in Tennessee, with 155 people being arrested, compared with 60 in Kentucky and 20 in West Virginia, according to the DEA.

The amount of meth collected from the states was more comparable, with 317 pounds from Tennessee, 360 pounds from Kentucky and 132 pounds from West Virginia.

"The amount of drugs and weapons we’ve taken off the street with this operation, along with the number of drug dealers that we’ve locked up, represents a small victory in our on-going fight for safer communities for us all,” D. Christopher Evans, Special Agent in Charge of DEA’s Louisville Division Office said. “While America’s opioid crisis may dominate headlines, Operation Crystal Mountain should serve as a reminder that methamphetamine is a problem that has never gone away."