It marks the second time the Vols will be featured on College GameDay this season. Tennessee beat Virginia Tech 45-25 in the Battle at Bristol on Sept. 10. Bristol became the 75th different city to host GameDay.
Knoxville last hosted GameDay against Florida on Sept. 15, 2012, when the Gators defeated the Vols at Neyland Stadium 37-20.
Saturday will mark the ninth time Knoxville has hosted GameDay.
The last time UT beat Florida was in 2004, which is also the last time the Vols won their first three consecutive games of the season.