Witherspoon has not revealed where in Nashville the store will be located.
The actress turned entrepreneur says the label is meant to honor her grandparents Dorothea Draper and William James Witherspoon, and to pay homage to her Nashville upbringing.
Draper James sells colorful and printed clothing, with prices ranging from $58 for a printed T-shirt to $300 for a dress. Accessories include jewelry, handbags, wallets, belts and hats. The home decor offerings include a custom cocktail napkin set, stationery, blankets and pillows.